We are excited to share the publication of the first-in-human clinical studyof COVAC-2, a recombinant protein subunit vaccine against COVID-19 formulated with Sepivac SWE™, an oil-in-water adjuvant co-developed by VFI and Seppic. Led by our long-standing partner Vaccine and Infectious Disease Organization (VIDO), the study confirms that the Sepivac SWE™-adjuvanted vaccine is safe and induces robust neutralizing antibody responses across age groups.
Read the article.
ISIDORe - “Integrated Services for Infectious Disease Outbreak Research”, has been officially launched on 24 February 2022. This 21M€ EU-funded large-scale project assembles an unprecedented One Health-driven, integrated portfolio of cutting-edge research services and resources, dedicated to the study of epidemic-prone diseases including SARS-CoV-2 variants. VFI offers a range of TransNational Access Services on adjuvants and formulation expertise in order to fight epidemic diseases.
For Press release read here
VFI is pleased to announce its continued partnership with VIDO, thanks to a 5M USD award from CEPI (Coalition of Epidemics Preparedness Innovations), to develop new vaccines that are broadly protective against COVID-19 variants and suitable for use in Low- and Middle-Income Countries. This work builds on the development of COVAC-2, VIDO’s subunit vaccine formulated with Sepivac SWE™, an adjuvant co-developed by Seppic and VFI.
Click here to read VIDO press release and CEPI press release
VFI is pleased to share news on positive Phase 1 results for COVAC-2, a COVID-19 subunit vaccine candidate developed by Usask's VIDO, formulated with Sepivac SWE™️, an adjuvant developed by VFI and Seppic. Click here to read the press release.
Start of COVAC-2 phase 1 clinical trial! A COVID-19 vaccine developed by VIDO which includes the open-access adjuvant Sepivac SWE, co-developed by VFI and Seppic.
VIDO’s COVID-19 vaccine receives Health Canada clinical trial approval for subunit-based vaccine combined to the open-access adjuvant Sepivac SWE, that was developed by Seppic in collaboration with VFI. First-in-human trials are planned in January 2021.
Sepivac SWE™ is prepared at cGMP-grade and is being made available to the entire vaccine community under open-access terms. Sepivac SWE™ adjuvant can be used in the composition of several vaccines including vaccines against seasonal influenza, pandemic influenza and COVID-19. A production capacity of several hundred million doses per year of Sepivac SWE™ is expected by summer 2021.
VFI is proud to have co-led the development of the first open-access adjuvant for prophylactic use since aluminium salts in the 1920’s and is grateful to its initial funders (European Commission, US-HHS BARDA and GIZ) for having catalysed the development of the SWE adjuvant. We look forward to continuing this long-term partnership with our Seppic colleagues.
With fitting measures, VFI laboratories will remain operational during the second wave of COVID-19 pandemic. We continue our vaccine development efforts in collaboration with the Bill & Melinda Gates Foundation and other partners in order to develop rapid solutions against the pandemic.
VFI and Seppic announced that they have finalized the development of an oil-in-water adjuvant at a Seppic plant in France. The adjuvant, manufactured under Good Manufactured Practices, will be openly available from Seppic before the end of this year, for the entire vaccine community.
As partner of TRANSVAC2, VFI offers its adjuvant and formulation services to vaccine researchers and developers in the context of Covid-19. Vaccine researchers and developers can ship their Sars-Cov-2 vaccine antigens to VFI for formulation with adjuvants suitable for clinical use. Once optimal formulations are identified, VFI can perform immunogenicity studies in mice including analyses of B- and T-cell responses. First deadline for application is 15 April 2020.
VFI is working with grantees from the Bill & Melinda Gates Foundation (BMGF) to evaluate Sars-Cov-2 vaccine candidates. Antigens provided by BMGF grantees are appropriately formulated with adjuvants developed by VFI with the ultimate goal to identify suitable Sars-Cov-2 vaccine candidates which can progress towards the clinic. This work is supported by the Global Health Vaccine Accelerator Platforms (GH-VAP) funded by BMGF.
VFI will support the vaccine community during Covid-19 pandemic. VFI is currently manufacturing several adjuvants to be included in upcoming Covid-19 studies and has secured access to animal facilities for immunogenicity studies of adjuvanted-Sars-Cov-2 vaccine formulations. VFI is also setting up collaborations with numerous vaccine developers worldwide in order to formulate Sars-Cov-2 vaccine candidates with VFI adjuvants to induce relevant immune responses.
